WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

FGFR3 is a prognostic and predictive marker and is a validated therapeutic target in
urothelial bladder cancer. Its utility as a marker and target in the context of immunotherapy is …

Abstract Serum interleukin-8 (IL-8) levels and tumor neutrophil infiltration are associated
with worse prognosis in advanced cancers. Here, using a large-scale retrospective analysis …

Background: Polymorphic adenoma-like protein 2 (PLAGL2), a zinc finger protein, has been
linked to the advancement of serval-type malignancies. However, the relevance of PLAGL2 …

Background & Aims Nivolumab, a programmed death (PD)-1 (PD-1) inhibitor, led to durable
responses, manageable safety, and increased survival in patients with advanced …

Summary Mutant p53 (mtp53) proteins can exert cancer-promoting gain-of-function
activities. We report a mechanism by which mtp53 suppresses both cell-autonomous and …

Background: Layilin (LAYN) is a critical gene that regulates T cell function. However, the
correlations of LAYN to prognosis and tumor-infiltrating lymphocytes in different cancers …

Background YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) has been indicated
proven to participate in the cross-presentation of tumor antigens in dendritic cells and the …

Purpose: Immune checkpoint inhibitors (ICI) have revolutionized cancer management.
However, molecular determinants of response to ICIs remain incompletely understood …

Triggering receptor expressed on myeloid cells-2 (TREM2) is a transmembrane receptor of
the immunoglobulin superfamily and a crucial signaling hub for multiple pathological …