The physiological responses of cells to external and internal stimuli are governed by genes
and proteins interacting in complex networks whose dynamical properties are impossible to …

A distinctive feature of many biological systems is their ability to adapt to persistent stimuli or
disturbances that would otherwise drive them away from a desirable steady state. The …

Directional guidance of cells via gradients of chemokines is considered crucial for
embryonic development, cancer dissemination, and immune responses. Nevertheless, the …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Many signaling systems show adaptation—the ability to reset themselves after responding to
a stimulus. We computationally searched all possible three-node enzyme network …

Advanced technologies and biology have extremely different physical implementations, but
they are far more alike in systems-level organization than is widely appreciated. Convergent …

In this article, we review physics-based models of collective cell motility. We discuss a range
of techniques at different scales, ranging from models that represent cells as simple self …

The opportunistic pathogen Pseudomonas aeruginosa explores surfaces using twitching
motility powered by retractile extracellular filaments called type IV pili (T4P). Single cells …

Cells have traditionally been viewed either as independently moving entities or as
somewhat static parts of tissues. However, it is now clear that in many cases, multiple cells …