Engineering tissues of the central nervous system: interfacing conductive biomaterials with neural stem/progenitor cells

RD Bierman‐Duquette, G Safarians… - Advanced …, 2022 - Wiley Online Library
Conductive biomaterials provide an important control for engineering neural tissues, where
electrical stimulation can potentially direct neural stem/progenitor cell (NS/PC) maturation …

State of the Art and Current challenges on Electroactive Biomaterials and strategies for neural tissue regeneration

T Marques‐Almeida… - Advanced …, 2024 - Wiley Online Library
The loss or failure of an organ/tissue stands as one of the healthcare system's most
prevalent, devastating, and costly challenges. Strategies for neural tissue repair and …

Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery

S Song, KW McConnell, D Amores, A Levinson… - Biomaterials, 2021 - Elsevier
Severe peripheral nerve injuries often result in permanent loss of function of the affected
limb. Current treatments are limited by their efficacy in supporting nerve regeneration and …

Conducting Polymer‐Based Granular Hydrogels for Injectable 3D Cell Scaffolds

VR Feig, S Santhanam, KW McConnell… - Advanced materials …, 2021 - Wiley Online Library
Injectable 3D cell scaffolds possessing both electrical conductivity and native tissue‐level
softness would provide a platform to leverage electric fields to manipulate stem cell …

Electrical modulation of transplanted stem cells improves functional recovery in a rodent model of stroke

B Oh, S Santhanam, M Azadian… - Nature …, 2022 - nature.com
Stroke is a leading cause of long-term disability worldwide, intensifying the need for effective
recovery therapies. Stem cells are a promising stroke therapeutic, but creating ideal …

Controlling properties of human neural progenitor cells using 2D and 3D conductive polymer scaffolds

S Song, D Amores, C Chen, K McConnell, B Oh… - Scientific Reports, 2019 - nature.com
Human induced pluripotent stem cell-derived neural progenitor cells (hNPCs) are a
promising cell source for stem cell transplantation to treat neurological diseases such as …

Stimulation strategies for electrical and magnetic modulation of cells and tissues

SA Omer, KH McKnight, LI Young, S Song - Cell Regeneration, 2023 - Springer
Electrical phenomena play an important role in numerous biological processes including
cellular signaling, early embryogenesis, tissue repair and remodeling, and growth of …

Conductive gradient hydrogels allow spatial control of adult stem cell fate

S Song, KW McConnell, D Shan, C Chen… - Journal of Materials …, 2024 - pubs.rsc.org
Electrical gradients are fundamental to physiological processes including cell migration,
tissue formation, organ development, and response to injury and regeneration. Current …

Conductive polymers to modulate the post-stroke neural environment

B Oh, P George - Brain research bulletin, 2019 - Elsevier
Despite the prevalence of stroke, therapies to augment recovery remain limited. Here we
focus on the use of conductive polymers for cell delivery, drug release, and electrical …

Combinatorial strategies for cell transplantation in traumatic spinal cord injury

V Jagrit, J Koffler, JN Dulin - Frontiers in Neuroscience, 2024 - frontiersin.org
Spinal cord injury (SCI) substantially reduces the quality of life of affected individuals.
Recovery of function is therefore a primary concern of the patient population and a primary …