Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

Stem-Cell Research and Clinical Application Stem cells have been the focus of hope, hype,
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …

Human pluripotent stem cell (hPSC)-derived islet cells provide promising resources for
diabetes studies, cell replacement treatment and drug screening. Recently, hPSC-derived …

Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune
destruction of insulin-producing β-pancreatic cells. Although many advances have been …

Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young
patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes …

The rising interest in human induced pluripotent stem cell (hiPSC)-derived organoid culture
has stemmed from the manipulation of various combinations of directed multi-lineage …

Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are
considered attractive sources of pancreatic β cells and islet organoids. Recently, several …

Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …

Limitations of monolayer culture conditions have motivated scientists to explore new models
that can recapitulate the architecture and function of human organs more accurately. Recent …

Organoid cultures are proving to be powerful in vitro models that closely mimic the cellular
constituents of their native tissue. Organoids are typically expanded and cultured in a 3D …