Simple Summary The role of human papillomavirus (HPV) in cervical carcinogenesis is
widely documented; however, with an increasing number of scientific publications on the …

Human Papillomavirus (HPV) type 16 oncoprotein E7 plays a major role in cervical
carcinogenesis by interacting with and functionally inactivating various host regulatory …

Epigenetics plays a key role in cancer development. Genetics alone cannot explain sporadic
cancer and cancer development in individuals with no family history or a weak family history …

We previously reported that a higher degree of methylation of CpG sites in the promoter
(positions 31, 37, 43, 52, and 58) and enhancer site 7862 of human papillomavirus (HPV) 16 …

Background Persistent infection with oncogenic Human Papillomavirus (HPV) is associated
with the development of cervical cancer with each genotype differing in their relative …

Two classes of Human papillomaviruses (HPV) infect the anogenital track: high risk viruses
that are associated with risk of cervical cancer and low risk types that drive development of …

The Homeobox (HOX) genes encode important transcription factors showing deregulated
expression in several cancers. However, their role in cervical cancer pathogenesis, remains …

Objective Many studies on integration have reported conflicting results regarding the role of
HPV integration in cervical cancer. We hypothesized that high viral load and disruption of E2 …

Methods: One hundred and thirty two pretreatment cervical tumour biopsies were selected
from patients undergoing radiotherapy alone (n= 63) or concomitant chemo-radiation (n …

High-risk human papillomaviruses are the etiological agents of cervical cancer and HPV16
is the most oncogenic genotype. Immortalization and transformation of infected cells …