The endoplasmic reticulum (ER) is responsible for structural transformation or folding of de
novo proteins for transport to the Golgi. When the folding capacity of the ER is exceeded or …

Retaining glycoside hydrolases use acid/base catalysis with an enzymatic acid/base
protonating the glycosidic bond oxygen to facilitate leaving-group departure alongside …

Natural flavonoids are capable of inhibiting glucosidase activity, so they can be used for
treating diabetes mellitus and hypertension. However, molecular-level details of their …

Abstract Background Grass carp (Ctenopharyngodon idella) is one of the most widely
cultivated fishes in China. High stocking density can reportedly affect fish growth and …

Divalent ligands were prepared as inhibitors for the adhesion protein of the problematic
Pseudomonas aeruginosa pathogen. Bridging two binding sites enables simultaneous …

Palladium-catalyzed oxidation of isopropyl N-acetyl-α-d-glucosamine (GlcNAc) is used to
prepare the rare sugars allosamine, lividosamine, and related compounds with …

Gaucher disease (GD) is a lysosomal storage disorder caused by inherited deficiencies in β‐
glucocerebrosidase (GBA). Current treatments require rapid disease diagnosis and a means …

Abstract Imidazo [1, 2-a] pyridines are present in numerous biologically active compounds
as the core structural motif. Herein, we report an asymmetric interrupted Barton-Zard …

The constant motivation for the synthesis of green products has attracted the attention of
researchers toward extremophiles and extremozymes. These naturally-derived, extreme …

Energy transfer engineering based on fluorescent probes for directly sensing enzyme
activities are in great demand as enzyme‐mediated transformations, which are central to all …