Electrospray ionization (ESI) is an essential technique for transferring proteins from solution
into the gas phase for mass spectrometry and ion mobility spectrometry. The mechanisms …

Ever since the inception of synthetic polymeric materials in the late 19th century, the number
of studies on polymers as well as the complexity of their structures have only increased. The …

Native mass spectrometry (MS) has become widely accepted in structural biology, providing
information on stoichiometry, interactions, homogeneity, and shape of protein complexes …

Ribonucleic acids (RNAs) remain challenging targets for structural biology, creating barriers
to understanding their vast functions in cellular biology and fully realizing their applications …

The precise relationship between native gas-phase protein ion structure, charge,
desolvation, and activation remains elusive. Much evidence supports the Charge Residue …

Mechanistic information about how gaseous ions are formed from charged droplets has
been difficult to establish because direct observation of nanodrops in a size range relevant …

Native ion mobility mass spectrometry is potentially useful for the biophysical
characterization of proteins, as the electrospray charge state distribution and the collision …

Recent advances in instrumentation and development of computational strategies for ion
mobility mass spectrometry (IM‐MS) studies have contributed to an extensive growth in the …

Studies of large proteins, protein complexes, and membrane protein complexes pose new
challenges, most notably the need for increased ion mobility (IM) and mass spectrometry …

Proteins can adopt different conformational states that are important for their biological
function and, in some cases, can be responsible for their dysfunction. The essential roles …