[HTML][HTML] Paracetamol metabolism by endothelial cells–Potential mechanism underlying intravenous paracetamol-induced hypotension
J Dannesboe, JA Bastrup, KH Nielsen, P Munck… - Pharmacological …, 2025 - Elsevier
It was shown previously that a metabolite of acetaminophen (APAP), N-acetyl-p-
benzoquinone imine (NAPQI), is a potent vasodilator, which could underlie the hypotension …
benzoquinone imine (NAPQI), is a potent vasodilator, which could underlie the hypotension …
Hepatotoxic assessment in a microphysiological system: Simulation of the drug absorption and toxic process after an overdosed acetaminophen on intestinal-liver-on …
Y Yu, B Sun, X Ye, Y Wang, M Zhao, J Song… - Food and Chemical …, 2024 - Elsevier
To compensate the limitation of animal models, new models were proposed for drug safety
evaluation to refine and reduce existing models. To mimic drug absorption and metabolism …
evaluation to refine and reduce existing models. To mimic drug absorption and metabolism …