Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

Lysosomal storage diseases (LSDs) are a group of rare genetic conditions. The absence or
deficiency of lysosomal proteins leads to excessive storage of undigested materials and …

Biomaterials may enhance neural repair after spinal cord injury (SCI) and testing their
functionality in large animals is essential to achieve successful clinical translation. This work …

Spinal cord injury has long been a prominent challenge in the trauma repair process. Spinal
cord injury is a research hotspot by virtue of its difficulty to treat and its escalating morbidity …

Abstract Background Aims In this article we aimed to provide an expert synthesis of the
current status of Schwann cell (SC) therapeutics and potential steps to increase their clinical …

Objective Through our previous clinical trials, the demonstrated therapeutic effects of MSC in
chronic spinal cord injury (SCI) were found to be not sufficient. Therefore, the need to …

Spinal cord injury (SCI) can permanently impair motor and sensory function and has a
devastating cost to patients and the United States healthcare system. Stem cell …

Spinal cord injury has long been a prominent challenge in the trauma repair process. Spinal
cord injury is a research hotspot by virtue of its difficulty to treat and its escalating morbidity …

The last three decades have witnessed transformative advances in biology and
neuroscience. Still, regeneration of axons after traumatic spinal cord injury (SCI) remains a …

This manuscript introduces the latest generation of a patient-mounted platform designed for
segmental injections of therapeutics direct into the spinal cord parenchyma. It emphasizes …