In the early nineties, few years before the birth of Europace, the clinical and scientific world
of familial arrhythmogenic conditions was revolutionized by the identification of the first …

Abstract Calcium (Ca2+) ions are a key second messenger involved in the rhythmic
excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+ …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by episodic
syncope occurring during exercise or acute emotion. The underlying cause of these …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

Cardiac diseases are the leading causes of death, with a growing number of cases
worldwide, posing a challenge for both healthcare and research. Therefore, the most …

The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel
RyR2 is an essential regulator of cardiac excitation–contraction coupling and intracellular …

Flecainide, a cardiac class 1C blocker of the surface membrane sodium channel (NaV1. 5),
has also been reported to reduce cardiac ryanodine receptor (RyR2)-mediated …

Ventricular arrhythmia without structural heart disease is an arrhythmic disorder that occurs
in structurally normal heart and no transient or reversible arrhythmia factors, such as …

Objective The aim of this study was to systematically review the evidence across studies that
assessed DNA methylome variations in association with food allergy (FA). Design A …

Background Different genes have been associated with idiopathic ventricular fibrillation
(IVF); however, there are no studies correlating genotype with phenotype. Objectives The …