Fluorescent tools have emerged as an important tool for studying the distinct chemical
microenvironments of organelles, due to their high specificity and ability to be used in non …

The biological effects of urolithins remain poorly characterized, despite wide-spread human
exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The vast number of implications of autophagy in multiple areas of life sciences and medicine
has attracted the interest of numerous scientists that aim to unveil the role of this process in …

Senescence, defined as irreversible cell-cycle arrest, is the main driving force of aging and
age-related diseases. Here, we performed high-throughput screening to identify compounds …

Biglycan, a small leucine-rich proteoglycan, acts as a danger signal and is classically
thought to promote macrophage recruitment via Toll-like receptors (TLR) 2 and 4. We have …

Coptisine is isoquinoline alkaloid derived from Coptidis Rhizoma and is known to have
potential anti-cancer activity toward various carcinomas. Targeting autophagy is one of the …

Pharmacological attenuation of mTOR presents a promising route for delay of age-related
disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin …

ABSTRACT SARS-CoV-2 poses a substantial global threat owing to the emergence of
several highly transmissible variants. Autophagy is an intracellular degradation process that …

Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in 25% of
acute myeloid leukemia (AML) patients, drive leukemia progression and confer a poor …