The intrinsic limitations of conventional dosages have facilitated the emergence of novel
drug delivery methodologies. Drug nanonization and encapsulation in polymeric …

Many serious infections result from persistent microbial biofilms that do not respond to
conventional antibiotic therapy. Various therapeutic approaches have been developed and …

Clinical investigation showed that voriconazole exhibits various adverse effects such as
nausea, vomiting, and other gastric disturbances. To overcome these associated side …

Superficial fungal infections manifesting the skin have become prevalent today. Even though
there has been a substantial number of antifungal drugs approved for treating topical fungal …

Background: Skin diseases affect all the age groups of people and have an impact on
patients' physical, mental, and emotional status. Conventional topical preparation is limited …

This study aims to develop chitosan-based voriconazole nanoparticles (NPs) using spray-
drying technique. The effect of surfactants and polymers on the physicochemical properties …

Objectives The present study was aimed to develop itraconazole (ITZL)-loaded NLC for the
treatment of fungal infection. Methods The formulation was prepared and optimized by the …

High-pressure homogenization (HPH) has been employed for unit operations like
comminution, mixing, and stabilization of pharmaceutical solids and nanoparticles. With …

Fungal infections have become a major health concern, given that invasive infections by
Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities …

Cryptococcus neoformans-mediated meningoencephalitis is a critical infectious disorder of
the human central nervous system. However, efficient treatment for the disease is limited …