Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal
point of cancer research. Accumulating evidence indicates a complex role for RB in cell …

The multistage process of carcinogenesis involves the progressive acquisition of mutations,
and epigenetic abnormalities in the expression, of multiple genes that have highly diverse …

The proper epigenetic modification of chromatin by protein arginine methyltransferases
(PRMTs) is crucial for normal cell growth and health. The human SWI/SNF-associated …

MicroRNAs (miRNA) play pivotal roles in controlling cell proliferation and differentiation.
Aberrant miRNA expression in human is becoming recognized as a new molecular …

Activated tumor stroma participates in tumor cell growth, invasion, and metastasis. Normal
fibroblasts and cancer-associated fibroblasts (CAFs) have been shown to display distinct …

Purpose Though the efficacy of MEK inhibitors is being investigated in KRAS-mutant
colorectal cancers (CRC), early clinical trials of MEK inhibitor monotherapy did not reveal …

The retinoblastoma tumor-suppressor gene (Rb1) is centrally important in cancer research.
Mutational inactivation of Rb1 causes the pediatric cancer retinoblastoma, while …

The E2F family of transcription factors is a central modulator of important cellular events,
including cell cycle progression, apoptosis and DNA damage response. The role of E2F …

The post-translational methylation of α-amino groups was first discovered over 30 years ago
on the bacterial ribosomal proteins L16 and L33 (refs,), but almost nothing is known about …

Wogonin, a naturally occurring mono-flavonoid, has been reported to have tumor
therapeutic potential and good selectivity both in vitro and in vivo. Herein, we investigated …