Current understanding of chromosome folding is largely reliant on chromosome
conformation capture (3C)-based experiments, where chromosomal interactions are …

Background In most mammalian cell lines, chromatin located at the nuclear periphery is
represented by condensed heterochromatin, as evidenced by microscopy observations and …

In many organisms, the regenerative capacity of tissues progressively decreases as
development progresses. However, the developmental mechanisms that restrict …

The spatial organization of chromosomes inside the eukaryotic nucleus is important for DNA
replication, repair and gene expression. During development of multicellular organisms …

Transcription factors govern many of the time-and tissue-specific gene expression events in
living organisms. CEH-60, a homolog of the TALE transcription factor PBX in vertebrates …

Circadian rhythms are essential physiological feature for most living organisms. Previous
studies have shown that epigenetic regulation plays a crucial role. There is a knowledge …

Heterochromatin protein 1a (HP1a) is a well-known component of pericentromeric and
telomeric heterochromatin in Drosophila. However, its role and the mechanisms of its …

Mammalian chromosomes are folded into an intricate hierarchy of structural domains, within
which topologically associating domains (TADs) and CTCF-associated loops partition the …

Gliomas account for approximately 30% of primary brain tumours and 80% of malignant
brain tumours. The clinical hallmarks are characterized as its aggressive growth and …