Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits

J Sharifi-Rad, C Quispe, M Imran, A Rauf… - Oxidative medicine …, 2021 - Wiley Online Library
Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …

Therapeutic potential of isoflavones with an emphasis on daidzein

MM Alshehri, J Sharifi-Rad… - Oxidative Medicine …, 2021 - Wiley Online Library
Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical
composition of daidzein is analogous to mammalian estrogens, and it could be useful with a …

Soy and health update: evaluation of the clinical and epidemiologic literature

M Messina - Nutrients, 2016 - mdpi.com
Soyfoods have long been recognized as sources of high-quality protein and healthful fat, but
over the past 25 years these foods have been rigorously investigated for their role in chronic …

Naturally occurring antioxidant therapy in Alzheimer's disease

AE Collins, TM Saleh, BE Kalisch - Antioxidants, 2022 - mdpi.com
It is estimated that the prevalence rate of Alzheimer's disease (AD) will double by the year
2040. Although currently available treatments help with symptom management, they do not …

Dietary flavonoids and human cognition: a meta‐analysis

N Cheng, L Bell, DJ Lamport… - Molecular nutrition & …, 2022 - Wiley Online Library
Improving cognition is important in all age groups, from performance in school examinations
to prevention of cognitive decline in later life. Dietary polyphenols, in particular flavonoids …

Lipid peroxidation and antioxidant supplementation in neurodegenerative diseases: a review of human studies

S Petrovic, A Arsic, D Ristic-Medic, Z Cvetkovic, V Vucic - Antioxidants, 2020 - mdpi.com
Being characterized by progressive and severe damage in neuronal cells,
neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the …

Dietary polyphenols as therapeutic intervention for Alzheimer's disease: a mechanistic insight

SNA Bukhari - Antioxidants, 2022 - mdpi.com
Dietary polyphenols encompass a diverse range of secondary metabolites found in nature,
such as fruits, vegetables, herbal teas, wine, and cocoa products, etc. Structurally, they are …

Isoflavones derived from plant raw materials: Bioavailability, anti-cancer, anti-aging potentials, and microbiome modulation

SA Aboushanab, SM Khedr, IF Gette… - Critical Reviews in …, 2022 - Taylor & Francis
Isoflavones are secondary metabolites that represent the most abundant category of plant
polyphenols. Dietary soy, kudzu, and red clover contain primarily genistein, daidzein …

[HTML][HTML] The protective effects of polyphenols on Alzheimer's disease: a systematic review

C Colizzi - Alzheimer's & Dementia: Translational Research & …, 2019 - Elsevier
Introduction Foods rich in polyphenols have been positively correlated to a reduced risk of
several noncommunicable diseases, including Alzheimer's disease (AD). The aim of this …

Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands

A Iraji, M Khoshneviszadeh, O Firuzi… - Bioorganic …, 2020 - Elsevier
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …