ErbB2‐NOTCH1 axis controls autophagy in cardiac cells

F Fortini, F Vieceli Dalla Sega, E Lazzarini… - …, 2024 - Wiley Online Library
Although the epidermal growth factor receptor 2 (ErbB2) and Notch1 signaling pathways
have both significant roles in regulating cardiac biology, their interplay in the heart remains …

Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models

G Aviel, J Elkahal, KB Umansky… - Nature Cardiovascular …, 2024 - nature.com
Myocardial injury may ultimately lead to adverse ventricular remodeling and development of
heart failure (HF), which is a major cause of morbidity and mortality worldwide. Given the …

Cardiomyocyte proliferation and regeneration in congenital heart disease

J Liang, X He, Y Wang - Pediatric Discovery, 2024 - Wiley Online Library
Despite advances in prenatal screening and a notable decrease in mortality rates,
congenital heart disease (CHD) remains the most prevalent congenital disorder in newborns …

Postnatal xanthine metabolism regulates cardiac regeneration in mammals

Y Saito, Y Sugiura, A Sakaguchi, T Sada, C Nishiyama… - bioRxiv, 2024 - biorxiv.org
Postnatal cardiomyocyte cell cycle withdrawal is a critical step wherein the mammalian heart
loses regenerative potential after birth. Here, we conducted interspecies multi-omic …