Mast cells have existed long before the development of adaptive immunity, although they
have been given different names. Thus, in the marine urochordate Styela plicata, they have …

Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage,
contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However …

Mast cells are primary effectors in allergic reactions, and may have important roles in
disease by secreting histamine and various inflammatory and immunomodulatory …

This review presents evidence that the skin mast cell, in particular the MCTC subtype, is the
primary effector cell in urticaria. Mast cells are located in the upper dermis, the ideal situation …

Background Wheal reactions to intradermally injected neuropeptides, such as substance P
(SP) and vasoactive intestinal peptide, are significantly larger and longer lasting in patients …

The Mas-related G protein–coupled receptor X2 (MRGPRX2) is a multiligand receptor
responding to various exogenous and endogenous stimuli. Being highly expressed on skin …

Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the
high-affinity receptor for immunoglobulin E (IgE) and have been linked to host defense and …

The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …

Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but
also play a fundamental role in innate and adaptive immune responses to microbial …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …