AHNAK: the giant jack of all trades

TA Davis, B Loos, AM Engelbrecht - Cellular signalling, 2014 - Elsevier
The nucleoprotein AHNAK is an unusual and somewhat mysterious scaffolding protein
characterised by its large size of approximately 700 kDa. Several aspects of this protein …

The obscure potential of AHNAK2

M Zardab, K Stasinos, RP Grose, HM Kocher - Cancers, 2022 - mdpi.com
Simple Summary AHNAK2 is a relatively newly discovered protein. It can interact with many
other proteins. This protein is increased in cells of variety of different cancers. AHNAK2 may …

AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer

B Chen, J Wang, D Dai, Q Zhou, X Guo, Z Tian… - Journal of Experimental …, 2017 - Springer
Background AHNAK, also known as desmoyokin, is a giant protein with the molecular size of
approximately 700 kDa and exerts diverse functions in different types of cancer. Results In …

[HTML][HTML] Ahnak depletion accelerates liver regeneration by modulating the TGF-β/Smad signaling pathway

I Yang, Y Son, JH Shin, IY Kim, JK Seong - BMB reports, 2022 - ncbi.nlm.nih.gov
Ahnak, a large protein first identified as an inhibitor of TGF-β signaling in human
neuroblastoma, was recently shown to promote TGF-β in some cancers. The TGF-β …

AHNAKs roles in physiology and malignant tumors

S Zhang, Z Cai, H Li - Frontiers in Oncology, 2023 - frontiersin.org
The AHNAK family currently consists of two members, namely AHNAK and AHNAK2, both of
which have a molecular weight exceeding 600 kDa. Homologous sequences account for …

AHNAK nucleoprotein 2 performs a promoting role in the proliferation and migration of uveal melanoma cells

M Li, Y Liu, Y Meng, Y Zhu - Cancer Biotherapy & …, 2019 - liebertpub.com
Abstract AHNAK nucleoprotein 2 (AHNAK2) is supposed to participate in calcium signaling
and cytoarchitecture by directly interacting with some proteins. Recently, it was identified as …

Flexible players within the sheaths: the intrinsically disordered proteins of myelin in health and disease

A Raasakka, P Kursula - Cells, 2020 - mdpi.com
Myelin ensheathes selected axonal segments within the nervous system, resulting primarily
in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the …

AHNAK2 is associated with poor prognosis and cell migration in lung adenocarcinoma

S Zhang, Y Lu, L Qi, H Wang, Z Wang… - BioMed Research …, 2020 - Wiley Online Library
Background. Lung adenocarcinoma (LUAD), as the main subtype of lung cancer, is one of
the common causes of cancer‐related deaths worldwide. The AHNAK family is correlated …

[HTML][HTML] Bioinformatics analysis of the clinical value and potential mechanisms of AHNAK2 in papillary thyroid carcinoma

Z Xie, Y Lun, X Li, Y He, S Wu, S Wang, J Sun… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Background: AHNAK2 has been recently reported as a biomarker in many cancers.
However, a systematic investigation of AHNAK2 in papillary thyroid carcinoma (PTC) has not …

Down-regulation of AHNAK2 inhibits cell proliferation, migration and invasion through inactivating the MAPK pathway in lung adenocarcinoma

DW Wang, HZ Zheng, N Cha… - … in cancer research …, 2020 - journals.sagepub.com
AHNAK nucleoprotein 2 (AHNAK2) has been emerged as a crucial protein for neuroblast
differentiation and cell migration, thereby involving in the development of various cancers …