Methods of determining responsiveness to anti-TNFα therapy in inflammatory bowel disease
JI Rotter, M Dubinsky, SR Targan… - US Patent 11,236,393, 2022 - Google Patents
The present invention relates to methods of prognosing responsiveness to anti-TNFa
therapy by determining the presence or absence of risk factors in the individual. In one …
therapy by determining the presence or absence of risk factors in the individual. In one …
Signature of TL1A (TNFSF15) signaling pathway
KS Michelsen, SR Targan - US Patent 10,316,083, 2019 - Google Patents
The present invention relates to the finding that TL1A enhances differentiation of TH17 cells,
and enhance IL17 secretion from TH17 cells. In one embodiment, the present invention …
and enhance IL17 secretion from TH17 cells. In one embodiment, the present invention …
Treatment and reversal of fibrosis and inflammation by inhibition of the TL1A-DR3 signaling pathway
DQ Shih, SR Targan, D Li, J Bilsborough - US Patent 10,633,449, 2020 - Google Patents
The invention relates to methods of treating fibrosis and inflammatory bowel disease. In one
embodiment, the present invention treats gut inflammation by administering a therapeutically …
embodiment, the present invention treats gut inflammation by administering a therapeutically …
Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
JI Rotter, KD Taylor, SR Targan, T Haritunians… - US Patent …, 2017 - Google Patents
Disclosed are methods of predicting the development of medically refractory ulcerative
colitis (MR-UC) in a patient In one embodiment, disclosed is a method of prognosing …
colitis (MR-UC) in a patient In one embodiment, disclosed is a method of prognosing …
Methods of diagnosing inflammatory bowel disease through RNASET2
R Gonsky, SR Targan, P Fleshner… - US Patent …, 2021 - Google Patents
Described herein are methods of diagnosing inflammatory bowel disease, including but not
limited to Crohn's Disease (CD), Ulcerative Colitis (UC), and/or Medically Refractive …
limited to Crohn's Disease (CD), Ulcerative Colitis (UC), and/or Medically Refractive …
Signature of TL1A (TNFSF15) signaling pathway
KS Michelsen, SR Targan - US Patent 11,312,768, 2022 - Google Patents
The present invention relates to the finding that TL1A enhances differentiation of TH17 cells,
and enhance IL17 secretion from TL17 cells. In one embodiment, the present invention …
and enhance IL17 secretion from TL17 cells. In one embodiment, the present invention …
Methods of determining responsiveness to anti-TNFα therapy in inflammatory bowel disease
JI Rotter, M Dubinsky, SR Targan… - US Patent 12,084,722, 2024 - Google Patents
The present invention relates to methods of prognosing responsiveness to anti-TNFα
therapy by determining the presence or absence of risk factors in the individual. In one …
therapy by determining the presence or absence of risk factors in the individual. In one …