Microglia are the resident macrophage population of the central nervous system (CNS).
Adequate microglial function is crucial for a healthy CNS. Microglia are not only the first …

The circulatory system is the first organ system to develop in the vertebrate embryo and is
critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of …

Allelic differences between the two homologous chromosomes can affect the propensity of
inheritance in humans; however, the extent of such differences in the human genome has …

Hematopoietic cell clusters in the aorta of vertebrate embryos play a pivotal role in the
formation of the adult blood system. Despite their importance, hematopoietic clusters have …

Objective—Two types of endothelial progenitor cells (EPCs), early EPCs and late EPCs
(also called endothelial outgrowth cells [EOCs]), were described in vitro previously. In this …

Haematopoietic stem cells (HSCs) are the founding cells of the adult haematopoietic system,
born during ontogeny from a specialized subset of endothelium, the haemogenic …

Abstract Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate
growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks …

Pluripotent embryonic stem cells (ESCs) are a potential source for cell‐based tissue
engineering and regenerative medicine applications, but their translation into clinical use …

Solid cancers are not simple accumulations of malignant tumor cells but rather represent
complex organ-like structures. Despite a more chaotic general appearance as compared to …

Background Notch receptor signaling controls developmental cell fates in a cell-context
dependent manner. Although Notch signaling directly regulates transcription via the RBP …