The ATP-driven chaperone valosin-containing protein (VCP)/p97 governs critical steps in
ubiquitin-dependent protein quality control and intracellular signalling pathways. It …

The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER
quality control (ERQC) system. The ERQC facilitates folding and modification of secretory …

Summary The Cdc48 ATPase and its cofactors Ufd1/Npl4 (UN) extract polyubiquitinated
proteins from membranes or macromolecular complexes, but how they perform these …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

p97 is a “segregase” that plays a key role in numerous ubiquitin (Ub)-dependent pathways
such as ER-associated degradation. It has been hypothesized that p97 extracts proteins …

Maintaining the functional integrity of mitochondria is pivotal for cellular survival. It appears
that neuronal homeostasis depends on high-fidelity mitochondria, in particular …

The hexameric type II AAA ATPase (ATPase associated with various activities) p97 (also
referred to as VCP, Cdc48, and Ter94) is critically involved in a variety of cellular activities …

Valosin‐containing protein (VCP) is an evolutionarily conserved ubiquitin‐dependent ATP
ase that mediates the degradation of proteins through the ubiquitin–proteasome pathway …

The AAA-type ATPase Cdc48 (named p97/VCP in mammals) is a molecular machine in all
eukaryotic cells that transforms ATP hydrolysis into mechanic power to unfold and pull …

p97/VCP/Cdc48 is one of the best-characterized type II AAA (ATPases associated with
diverse cellular activities) ATPases. p97 is suggested to be a ubiquitin-selective chaperone …