Allostery is a nearly ubiquitous feature of biological systems in which ligand binding or
covalent modification at one site alters the activities of distant sites in a macromolecule or …

C-type inactivation in potassium channels helps fine-tune long-term channel activity through
conformational changes at the selectivity filter. Here, through the use of cross-linked …

Voltage-gated potassium (Kv) channels modulate the function of electrically-excitable and
non-excitable cells by using several types of “gates” to regulate ion flow through the …

Calcium-dependent inactivation (CDI) is a fundamental autoregulatory mechanism in Ca V 1
and Ca V 2 voltage-gated calcium channels. Although CDI initiates with the cytoplasmic …

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a ubiquitous
mechanism that generates transcriptomic diversity. This process is particularly important for …

In Shaker K+ channels, the S4-S5 linker couples the voltage sensor (VSD) and pore domain
(PD). Another coupling mechanism is revealed using two W434F-containing channels …

Voltage-gated K+ (Kv) channels mediate the flow of K+ across the cell membrane by
regulating the conductive state of their activation gate (AG). Several Kv channels display …

The slow spontaneous inactivation of potassium channels exhibits classic signatures of
transmembrane allostery. A variety of data support a model in which the loss of K+ ions from …

Mode-shift or hysteresis has been reported in ion channels. Voltage-shift for gating currents
is well documented for voltage-gated cation channels (VGCC), and it is considered a voltage …

The selectivity filter and the activation gate in potassium channels are functionally and
structurally coupled. An allosteric coupling underlies C-type inactivation coupled to …