Adherens junctions (AJs) and desmosomes connect the actin and keratin filament networks
of adjacent cells into a mechanical unit. Whereas AJs function in mechanosensing and in …

The development of adhesive connections between cells was critical for the evolution of
multicellularity and for organizing cells into complex organs with discrete compartments …

As the first line of defense against risk factors, the nasal epithelial barrier maintains
homeostasis in nasal mucosa. The composition of the epithelial barrier contains physical …

Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and
mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein …

Desmosomes are relatives of ancient cadherin-based junctions, which emerged late in
evolution to ensure the structural integrity of vertebrate tissues by coupling the intermediate …

Pemphigus is a severe autoimmune-blistering disease of the skin and mucous membranes
caused by autoantibodies reducing desmosomal adhesion between epithelial cells …

Desmosomes are cell-cell adhesive organelles with a well-known role in forming strong
intercellular adhesion during embryogenesis and in adult tissues subject to mechanical …

Desmosomes provide strong intercellular cohesion essential for the integrity of cells and
tissues exposed to continuous mechanical stress. For desmosome assembly, constitutively …

Rationale: The sympathetic nervous system is a major mediator of heart function.
Intercalated discs composed of desmosomes, adherens junctions, and gap junctions …

The intestinal mucosa is lined by a single layer of epithelial cells that forms a tight barrier,
separating luminal antigens and microbes from underlying tissue compartments. Mucosal …