Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

The past three decades have borne witness to many advances in the understanding of the
molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein–Barr virus …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …

During the course of malignant cancer progression, neoplastic cells undergo dynamic and
reversible transitions between multiple phenotypic states, the extremes of which are defined …

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

The importance of the physiological function of phosphatase and tensin homologue (PTEN)
is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3 …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Renal fibrosis, irrespective of its etiology, is a final common stage of almost all chronic
kidney diseases. Increased apoptosis, epithelial‐to‐mesenchymal transition, and …