Nanotechnology: intelligent design to treat complex disease

P Couvreur, C Vauthier - Pharmaceutical research, 2006 - Springer
The purpose of this expert review is to discuss the impact of nanotechnology in the treatment
of the major health threats including cancer, infections, metabolic diseases, autoimmune …

Respiratory syncytial virus infection in elderly adults

AR Falsey, EE Walsh - Drugs & aging, 2005 - Springer
Respiratory syncytial virus (RSV) infection is now recognised as a significant problem in
elderly adults. Epidemiological evidence indicates the impact of RSV in older adults may be …

Inhibition of respiratory viruses by nasally administered siRNA

V Bitko, A Musiyenko, O Shulyayeva, S Barik - Nature medicine, 2005 - nature.com
Respiratory syncytial virus (RSV) and parainfluenza virus (PIV) are two respiratory
pathogens of paramount medical significance that exert high mortality. At present, there is no …

Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-κB-dependent, interferon-independent mechanism and facilitate virus …

V Bitko, O Shulyayeva, B Mazumder… - Journal of …, 2007 - Am Soc Microbiol
The two nonstructural (NS) proteins NS1 and NS2 of respiratory syncytial virus (RSV) are
abundantly expressed in the infected cell but are not packaged in mature progeny virions …

Antiviral activity and mode of action of caffeoylquinic acids from Schefflera heptaphylla (L.) Frodin

Y Li, PPH But, VEC Ooi - Antiviral Research, 2005 - Elsevier
Schefflera heptaphylla is a popular medicinal plant in southern China. Three caffeoylquinic
acid derivatives, namely 3, 4-di-O-caffeoylquinic acid, 3, 5-di-O-caffeoylquinic acid, and 3-O …

RSV604, a novel inhibitor of respiratory syncytial virus replication

J Chapman, E Abbott, DG Alber… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract
infections worldwide, yet no effective vaccine or antiviral treatment is available. Here we …

Pharmacologic advances in the treatment and prevention of respiratory syncytial virus

LD Saravolatz, KM Empey… - Clinical Infectious …, 2010 - academic.oup.com
Currently, only 2 drugs have been approved for the treatment of respiratory syncytial virus
(RSV). Palivizumab is a monoclonal antibody for the prevention of RSV in high-risk children …

Short interfering RNA (siRNA): tool or therapeutic?

D Cejka, D Losert, V Wacheck - Clinical science, 2006 - portlandpress.com
Gene silencing by siRNA (short interfering RNA) is a still developing field in biology and has
evolved as a novel post-transcriptional gene silencing strategy with therapeutic potential …

Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation

BD Persson, AB Jaffe, R Fearns, H Danahay - PloS one, 2014 - journals.plos.org
Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality worldwide,
causing severe respiratory illness in infants and immune compromised patients. The ciliated …

Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections

A Guerrero-Plata, S Baron, JS Poast… - Journal of …, 2005 - Am Soc Microbiol
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) cause a similar
spectrum of respiratory infections in humans. Classified within the Paramyxoviridae family …