An overview of molecular hybrids in drug discovery
G Bérubé - Expert opinion on drug discovery, 2016 - Taylor & Francis
Introduction: The hybridization of biologically active molecules is a powerful tool for drug
discovery used to target a variety of diseases. It offers the prospect of better drugs for the …
discovery used to target a variety of diseases. It offers the prospect of better drugs for the …
Recent advancements in 1, 4-disubstituted 1H-1, 2, 3-triazoles as potential anticancer agents
K Lal, P Yadav - Anti-Cancer Agents in Medicinal Chemistry …, 2018 - ingentaconnect.com
Cancer is a class of formidable disease with high degree of mortality. Despite much
progress in chemotherapy, the problem of drug resistance has led to the search for newer …
progress in chemotherapy, the problem of drug resistance has led to the search for newer …
Green synthesis and anticancer potential of chalcone linked-1, 2, 3-triazoles
A series of chalcone linked-1, 2, 3-triazoles was synthesized via cellulose supported copper
nanoparticle catalyzed click reaction in water. The structures of all the compounds were …
nanoparticle catalyzed click reaction in water. The structures of all the compounds were …
Synthesis of newer 1, 2, 3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities
The present study was carried out in an attempt to synthesize a new class of antimicrobial
and antiplasmodial agents by copper catalyzed click chemistry to afford 25 compounds 10 …
and antiplasmodial agents by copper catalyzed click chemistry to afford 25 compounds 10 …
Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1, 2, 3-triazole conjugates
A simple and green synthesis of some fluorinated chalcone-triazole hybrids from
propargylated chalcones and organic azides catalyzed by cellulose supported copper …
propargylated chalcones and organic azides catalyzed by cellulose supported copper …
Small hybrid heteroaromatics: Resourceful biological tools in cancer research
Nowadays, hybrid drugs containing two or more covalently linked known potential
pharmacophores are designed to simultaneously modulate multiple targets of multifactorial …
pharmacophores are designed to simultaneously modulate multiple targets of multifactorial …
A Synthetic Overview of Benzoxazines and Benzoxazepines as Anticancer Agents
Benzoxazines and benzoxazepines are nitrogen and oxygen‐containing six and seven‐
membered benzo‐fused heterocyclic scaffolds, respectively. Benzoxazepines and …
membered benzo‐fused heterocyclic scaffolds, respectively. Benzoxazepines and …
Design, synthesis, structural characterization and in vitro evaluation of new 1, 4-disubstituted-1, 2, 3-triazole derivatives against glioblastoma cells
VD da Silva, BM de Faria, E Colombo, L Ascari… - Bioorganic …, 2019 - Elsevier
Abstract A new series of 1, 4-disubstituted-1, 2, 3-triazole derivatives were synthesized
through the copper-catalyzed azide-alkyne 1, 3-dipolar cycloaddition (Click chemistry) and …
through the copper-catalyzed azide-alkyne 1, 3-dipolar cycloaddition (Click chemistry) and …
Synthesis and anti-proliferative activity of a novel 1, 2, 3-triazole tethered chalcone acetamide derivatives
S Vanaparthi, R Bantu, N Jain, S Janardhan… - Bioorganic & Medicinal …, 2020 - Elsevier
Abstract A new series of 1, 2, 3-triazole tethered chalcone acetamide derivatives (7a-c & 8a-
r) have been synthesized in excellent yields and their structures were determined by …
r) have been synthesized in excellent yields and their structures were determined by …
Design, synthesis and in vitro anti-tuberculosis activity of benzo [6, 7] cyclohepta [1, 2-b] pyridine-1, 2, 3-triazole derivatives
Y Sajja, S Vanguru, HR Vulupala, R Bantu… - Bioorganic & medicinal …, 2017 - Elsevier
A series of novel benzo [6, 7] cyclohepta [1, 2-b] pyridine-1, 2, 3-triazole hybrids (7a–j & 8a–
j) have been designed and synthesized in excellent yields by Huisgen's [3+ 2] cyclo addition …
j) have been designed and synthesized in excellent yields by Huisgen's [3+ 2] cyclo addition …