Turning liabilities into opportunities: Off-target based drug repurposing in cancer
Targeted drugs and precision medicine have transformed the landscape of cancer therapy
and significantly improved patient outcomes in many cases. However, as therapies are …
and significantly improved patient outcomes in many cases. However, as therapies are …
Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations
CR Bell, VS Pelly, A Moeini, SC Chiang… - Nature …, 2022 - nature.com
Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-
dependent tumor growth control or paradoxically accelerate tumor progression. The …
dependent tumor growth control or paradoxically accelerate tumor progression. The …
Connecting omics signatures and revealing biological mechanisms with iLINCS
There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …
and interfaces for integrative analyses and visualization that do not require programming …
mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 are druggable candidates for N-(2, 4-difluorophenyl)-2′, 4′-difluoro-4-hydroxybiphenyl-3-carboxamide (NSC765598) …
Background The application of computational and multi-omics approaches has aided our
understanding of carcinogenesis and the development of therapeutic strategies …
understanding of carcinogenesis and the development of therapeutic strategies …
Chromatin remodeling and immediate early gene activation by SLFN11 in response to replication stress
Summary Schlafen 11 (SLFN11) was recently discovered as a cellular restriction factor
against replication stress. Here, we show that SLFN11 increases chromatin accessibility …
against replication stress. Here, we show that SLFN11 increases chromatin accessibility …
[HTML][HTML] Q-omics: smart software for assisting oncology and cancer research
J Lee, Y Kim, S Jin, H Yoo, S Jeong, E Jeong, S Yoon - Molecules and cells, 2021 - Elsevier
The rapid increase in collateral omics and phenotypic data has enabled data-driven studies
for the fast discovery of cancer targets and biomarkers. Thus, it is necessary to develop …
for the fast discovery of cancer targets and biomarkers. Thus, it is necessary to develop …
Quantitative proteome landscape of the NCI-60 cancer cell lines
Here we describe a proteomic data resource for the NCI-60 cell lines generated by pressure
cycling technology and SWATH mass spectrometry. We developed the DIA-expert software …
cycling technology and SWATH mass spectrometry. We developed the DIA-expert software …
Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers
Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its
immediate consequence, aneuploidy, trigger adverse effects on cellular homeostasis that …
immediate consequence, aneuploidy, trigger adverse effects on cellular homeostasis that …
Sorafenib inhibits ribonucleotide reductase regulatory subunit M2 (RRM2) in hepatocellular carcinoma cells
PM Yang, LS Lin, TP Liu - Biomolecules, 2020 - mdpi.com
The main curative treatments for hepatocellular carcinoma (HCC) are surgical resection and
liver transplantation, which only benefits 15% to 25% of patients. In addition, HCC is highly …
liver transplantation, which only benefits 15% to 25% of patients. In addition, HCC is highly …
Molecular basis of GDF15 induction and suppression by drugs in cardiomyocytes and cancer cells toward precision medicine
LM Winter, D Reinhardt, A Schatter, V Tissen… - Scientific Reports, 2023 - nature.com
GDF15 has recently emerged as a key driver of the development of various disease
conditions including cancer cachexia. Not only the tumor itself but also adverse effects of …
conditions including cancer cachexia. Not only the tumor itself but also adverse effects of …