Forging a field: the golden age of iron biology
NC Andrews - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
Oh what a difference a decade makes! In a landmark paper published in 1996, Feder and
colleagues identified the long-sought gene mutated in patients with classical hereditary …
colleagues identified the long-sought gene mutated in patients with classical hereditary …
Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD
JL Babitt, HY Lin - American journal of kidney diseases, 2010 - Elsevier
Anemia is prevalent in patients with chronic kidney disease (CKD) and is associated with
lower quality of life and higher risk of adverse outcomes, including cardiovascular disease …
lower quality of life and higher risk of adverse outcomes, including cardiovascular disease …
The serine protease TMPRSS6 is required to sense iron deficiency
X Du, E She, T Gelbart, J Truksa, P Lee, Y Xia… - Science, 2008 - science.org
Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of
body iron content. Several proteins induce expression of the hepcidin-encoding gene Hamp …
body iron content. Several proteins induce expression of the hepcidin-encoding gene Hamp …
Targeting the hepcidin–ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation
Anemia of chronic disease (ACD) or anemia of inflammation is prevalent in patients with
chronic infection, autoimmune disease, cancer, and chronic kidney disease. ACD is …
chronic infection, autoimmune disease, cancer, and chronic kidney disease. ACD is …
Iron absorption and metabolism
GJ Anderson, DM Frazer… - Current opinion in …, 2009 - journals.lww.com
Disturbances in the hepcidin regulatory pathway underlie a range of iron metabolism
disorders, from iron deficiency to iron loading, and there is considerable promise that the …
disorders, from iron deficiency to iron loading, and there is considerable promise that the …
Extramedullary hematopoiesis: a new look at the underlying stem cell niche, theories of development, and occurrence in animals
JL Johns, MM Christopher - Veterinary pathology, 2012 - journals.sagepub.com
Extramedullary hematopoiesis (EMH) is the formation and development of blood cells
outside the medullary spaces of the bone marrow. Although widely considered an …
outside the medullary spaces of the bone marrow. Although widely considered an …
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
Hemojuvelin (HJV) is a coreceptor for bone morphogenetic protein (BMP) signaling that
regulates hepcidin expression and iron metabolism. However, the precise combinations of …
regulates hepcidin expression and iron metabolism. However, the precise combinations of …
Iron regulation and erythropoiesis
E Nemeth - Current opinion in hematology, 2008 - journals.lww.com
Iron regulation and erythropoiesis : Current Opinion in Hematology Iron regulation and
erythropoiesis : Current Opinion in Hematology Log in or Register Subscribe to journalSubscribe …
erythropoiesis : Current Opinion in Hematology Log in or Register Subscribe to journalSubscribe …
Molecular mechanisms of normal iron homeostasis
AS Zhang, CA Enns - ASH Education Program Book, 2009 - ashpublications.org
Humans possess elegant control mechanisms to maintain iron homeostasis by coordinately
regulating iron absorption, iron recycling, and mobilization of stored iron. Dietary iron …
regulating iron absorption, iron recycling, and mobilization of stored iron. Dietary iron …
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
The hemochromatosis proteins HFE, transferrin receptor 2 (TfR2) and hemojuvelin (HJV,
HFE2) positively control expression of the major iron regulatory hormone hepcidin. HJV is a …
HFE2) positively control expression of the major iron regulatory hormone hepcidin. HJV is a …