Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies

A Jurcau, A Simion - International journal of molecular sciences, 2021 - mdpi.com
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

N Amruta, WH Chastain, M Paz, RJ Solch… - Cytokine & growth factor …, 2021 - Elsevier
SARS-CoV-2 is a novel coronavirus that severely affects the respiratory system, is the cause
of the COVID-19 pandemic, and is projected to result in the deaths of 2 million people …

Cellular and Molecular targets for Non-Invasive, non-pharmacological Therapeutic/Rehabilitative interventions in Acute ischemic stroke

G Onose, A Anghelescu, D Blendea, V Ciobanu… - International Journal of …, 2022 - mdpi.com
BACKGROUND: Cerebral circulation delivers the blood flow to the brain through a
dedicated network of sanguine vessels. A healthy human brain can regulate cerebral blood …

Three-dimensional-cultured MSC-derived exosome with hydrogel for cerebral ischemia repair

M Han, Z Zhang, Z Liu, Y Liu, H Zhao, B Wang… - Biomaterials …, 2023 - Elsevier
Microglia-mediated neuroinflammatory response, one of the most essential pathological
processes of cerebral ischemia-reperfusion (I/R) injury, is acknowledged as the main factors …

Neuroglia in cognitive reserve

A Verkhratsky, R Zorec - Molecular psychiatry, 2024 - nature.com
The concept of cognitive reserve was born to account for the disjunction between the
objective extent of brain damage in pathology and its clinical and intellectual outcome. The …

The organism as the niche: physiological states crack the code of adult neural stem cell heterogeneity

Z Chaker, E Makarouni, F Doetsch - Annual Review of Cell and …, 2024 - annualreviews.org
Neural stem cells (NSCs) persist in the adult mammalian brain and are able to give rise to
new neurons and glia throughout life. The largest stem cell niche in the adult mouse brain is …

Signaling pathways in brain ischemia: Mechanisms and therapeutic implications

W Lin, XY Zhao, J Cheng, L Li, Q Jiang… - Pharmacology & …, 2023 - Elsevier
Ischemic stroke occurs when the arteries supplying blood to the brain are narrowed or
blocked, inducing damage to brain tissue due to a lack of blood supply. One effective way to …

Endogenous neural stem cell–induced neurogenesis after ischemic stroke: processes for brain repair and perspectives

H Tang, Y Li, W Tang, J Zhu, GC Parker… - Translational Stroke …, 2023 - Springer
Ischemic stroke is a very common cerebrovascular accident that occurred in adults and
causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe …

Direct neuronal reprogramming: bridging the gap between basic science and clinical application

L Vasan, E Park, LA David, T Fleming… - Frontiers in Cell and …, 2021 - frontiersin.org
Direct neuronal reprogramming is an innovative new technology that involves the
conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent …

mTOR (mammalian target of rapamycin): hitting the bull's eye for enhancing neurogenesis after cerebral ischemia?

J Gao, M Yao, D Chang, J Liu - Stroke, 2023 - Am Heart Assoc
Ischemic stroke remains a leading cause of morbidity and disability around the world. The
sequelae of serious neurological damage are irreversible due to body's own limited repair …