Airway surface liquid pH regulation in airway epithelium current understandings and gaps in knowledge

M Zajac, E Dreano, A Edwards, G Planelles… - International journal of …, 2021 - mdpi.com
Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …

The chloride anion as a signalling effector

ÁG Valdivieso, TA Santa‐Coloma - Biological Reviews, 2019 - Wiley Online Library
The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

Glycolysis Reprogramming in Idiopathic Pulmonary Fibrosis: Unveiling the Mystery of Lactate in the Lung

P Yan, J Liu, Z Li, J Wang, Z Zhu, L Wang… - International Journal of …, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized
by excessive deposition of fibrotic connective tissue in the lungs. Emerging evidence …

CFTR dysfunction leads to defective bacterial eradication on cystic fibrosis airways

M Wu, JH Chen - Frontiers in Physiology, 2024 - frontiersin.org
Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) anion
channel by genetic mutations causes the inherited disease cystic fibrosis (CF). CF lung …

Epidermal growth factor receptor activity upregulates lactate dehydrogenase A expression, lactate dehydrogenase activity, and lactate secretion in cultured IB3-1 …

MM Massip-Copiz, ÁG Valdivieso… - … and Cell Biology, 2021 - cdnsciencepub.com
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) gene. It has been postulated that reduced HCO3− transport through CFTR …

Human airway epithelial cell pH regulatory proteins in cystic fibrosis: Differential expression in nasal and bronchial airway cells

MD Davis, B Gaston, L Smith, RA Rahman, F Khalid… - 2023 - researchsquare.com
Background. Decreased apical bicarbonate transport into the airway surface liquid (ASL)
has been associated with decreased ASL pH in some studies. Low ASL pH can have …

Regulación del gen PEIG-1/GPRC5A por 12-O-tetradecanoilforbol-13-acetato

C Mori - 2020 - sedici.unlp.edu.ar
Los receptores acoplados a proteínas G (“G protein-coupled receptors”, GPCRs), son
proteínas integrales de membrana en la superficie celular y pertenecen a una de las …