Drosophila as an In Vivo Model for Human Neurodegenerative Disease
With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …
Choosing an animal model for the study of Huntington's disease
MA Pouladi, AJ Morton, MR Hayden - Nature Reviews Neuroscience, 2013 - nature.com
Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …
animal models of this disorder have been developed. A frequently asked question is: which …
A liquid to solid phase transition underlying pathological huntingtin exon1 aggregation
Huntington's disease is caused by an abnormally long polyglutamine tract in the huntingtin
protein. This leads to the generation and deposition of N-terminal exon1 fragments of the …
protein. This leads to the generation and deposition of N-terminal exon1 fragments of the …
α-Synuclein impairs macroautophagy: implications for Parkinson's disease
AR Winslow, CW Chen, S Corrochano… - Journal of Cell …, 2010 - rupress.org
Parkinson's disease (PD) is characterized pathologically by intraneuronal inclusions called
Lewy bodies, largely comprised of α-synuclein. Multiplication of the α-synuclein gene locus …
Lewy bodies, largely comprised of α-synuclein. Multiplication of the α-synuclein gene locus …
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Huntington disease is one of nine inherited neurodegenerative disorders caused by a
polyglutamine tract expansion. Expanded polyglutamine proteins accumulate abnormally in …
polyglutamine tract expansion. Expanded polyglutamine proteins accumulate abnormally in …
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
H Nishitoh, A Matsuzawa, K Tobiume… - Genes & …, 2002 - genesdev.cshlp.org
Expansion of CAG trinucleotide repeats that encode polyglutamine is the underlying cause
of at least nine inherited human neurodegenerative disorders, including Huntington's …
of at least nine inherited human neurodegenerative disorders, including Huntington's …
Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
Parkinson's disease is a movement disorder characterized by degeneration of dopaminergic
neurons in the substantia nigra pars compacta. Dopaminergic neuronal loss also occurs in …
neurons in the substantia nigra pars compacta. Dopaminergic neuronal loss also occurs in …
Comparative genomics of the eukaryotes
A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis
elegans, and Saccharomyces cerevisiae—and the proteins they are predicted to encode …
elegans, and Saccharomyces cerevisiae—and the proteins they are predicted to encode …
Glutamine repeats and neurodegeneration
A growing number of neurodegenerative diseases have been found to result from the
expansion of an unstable trinucleotide repeat. Over the past 6 years, researchers have …
expansion of an unstable trinucleotide repeat. Over the past 6 years, researchers have …
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
Members of the myocyte enhancer factor-2 (MEF2) family of transcription factors associate
with myogenic basic helix–loop–helix transcription factors such as MyoD to activate skeletal …
with myogenic basic helix–loop–helix transcription factors such as MyoD to activate skeletal …