The events that convert adherent epithelial cells into individual migratory cells that can
invade the extracellular matrix are known collectively as epithelial-mesenchymal transition …

Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

MicroRNAs (miRNAs) are emerging as important, albeit poorly characterized, regulators of
biological processes. Key to further elucidation of their roles is the generation of more …

Abstract The International Stem Cell Initiative characterized 59 human embryonic stem cell
lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques …

When cultured in suspension without antidifferentiation factors, embryonic stem (ES) cells
spontaneously differentiate and form three-dimensional multicellular aggregates called …

Developmental biology has long benefited from studies of classic model organisms.
Recently, human pluripotent stem cells (hPSCs), including human embryonic stem cells and …

Human embryonic stem cells have been defined as self-renewing cells that can give rise to
many types of cells of the body. How and whether these cells can be manipulated to replace …

Differentiated cell types derived from human embryonic stem cells (hESCs) may serve in the
future to treat various human diseases. A crucial step toward their successful clinical …

Embryonic stem cells (ESCs) are pluripotent cells capable of differentiating into all somatic
and germ cell types. The intrinsic ability of pluripotent cells to generate a vast array of …

The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early
mammalian embryo and is highly expressed in the inner cell mass of the blastocyst …