The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …

Simple Summary Post-translational modifications (PTM) of histone tails represent
epigenomic regulation of the chromatin landscape, influencing gene expression and the …

Chromatin remodeling and N 6-methyladenosine (m 6 A) modification are two critical layers
in controlling gene expression and DNA damage signaling in most eukaryotic bioprocesses …

Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is implicated in the control of
multiple essential processes, including transcription, DNA damage repair and mitotic …

The non-canonical Wnt signalling receptor ROR1 is aberrantly expressed in numerous
cancers, including ovarian and endometrial cancer. We previously reported that silencing …

Epithelial–mesenchymal transition (EMT) plays essential roles in promoting malignant
transformation of epithelial cells, leading to cancer progression and metastasis. During EMT …

Posttranslational histone modifications play important roles in regulating chromatin structure
and transcriptional regulation. Histone H2B monoubiquitination (H2Bub) is an essential …

Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase
inhibitor (EGFR-TKI) approved for patients with EGFR T790M resistance mutations as first-or …

Therapy resistance remains the most challenging obstacle in cancer treatment. Substantial
efforts and evidences have accumulated over decades suggesting not only genetic but non …

Ubiquitination is a critical type of protein post-translational modification playing an essential
role in many cellular processes. To date, more than eight types of ubiquitination exist, all of …