Endoplasmic reticulum (ER)‐localized enzymes synthesize the vast majority of cellular
lipids. The ER therefore has a major influence on cellular lipid biomass and balances the …

The four main types of biomolecules are nucleic acids, proteins, carbohydrates and lipids.
The knowledge about their respective interactions is as important as the individual …

Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope
and are composed of KASH and SUN proteins residing in the outer and inner nuclear …

Lamina-associated polypeptide 1 (LAP1) resides at the nuclear envelope and interacts with
Torsins, poorly understood endoplasmic reticulum (ER)-localized AAA+ ATPases, through a …

The nuclear envelope (NE) is a subdomain of the ER with prominent roles in nuclear
organization, which are largely mediated by its distinctive protein composition. We …

The nucleus is positioned toward the rear of most migratory cells. In fibroblasts and
myoblasts polarizing for migration, retrograde actin flow moves the nucleus rearward …

Depletion of torsinA from hepatocytes leads to reduced liver triglyceride secretion and
marked hepatic steatosis. TorsinA is an atypical ATPase that lacks intrinsic activity unless it …

Torsins are membrane-associated ATPases whose activity is dependent on two activating
cofactors, lamina-associated polypeptide 1 (LAP1) and luminal domain-like LAP1 (LULL1) …

The most common cause of early onset primary dystonia, a neuromuscular disease, is a
glutamate deletion (ΔE) at position 302/303 of TorsinA, a AAA+ ATPase that resides in the …

The nuclear pore complex (NPC) is among the most elaborate protein complexes in
eukaryotes. While ribosomes and proteasomes are known to require dedicated assembly …