The cGAS–STING pathway as a therapeutic target in inflammatory diseases
A Decout, JD Katz, S Venkatraman… - Nature Reviews …, 2021 - nature.com
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
Structures and mechanisms in the cGAS-STING innate immunity pathway
Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
L Zhang, X Wei, Z Wang, P Liu, Y Hou, Y Xu, H Su… - Cell Reports, 2023 - cell.com
It is widely known that stimulator of interferon genes (STING) can trigger nuclear factor κB
(NF-κB) signaling. However, whether and how the NF-κB pathway affects STING signaling …
(NF-κB) signaling. However, whether and how the NF-κB pathway affects STING signaling …
DNA sensing by the cGAS–STING pathway in health and disease
The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
Design of amidobenzimidazole STING receptor agonists with systemic activity
JM Ramanjulu, GS Pesiridis, J Yang, N Concha… - Nature, 2018 - nature.com
Stimulator of interferon genes (STING) is a receptor in the endoplasmic reticulum that
propagates innate immune sensing of cytosolic pathogen-derived and self DNA. The …
propagates innate immune sensing of cytosolic pathogen-derived and self DNA. The …
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
Infections by pathogens that contain DNA trigger the production of type-I interferons and
inflammatory cytokines through cyclic GMP–AMP synthase, which produces 2′ 3′-cyclic …
inflammatory cytokines through cyclic GMP–AMP synthase, which produces 2′ 3′-cyclic …
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
T Li, ZJ Chen - Journal of Experimental Medicine, 2018 - rupress.org
Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host
immune system to mount a defense response to microbial infections. However, this detection …
immune system to mount a defense response to microbial infections. However, this detection …
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
Innate DNA sensing via the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …
[HTML][HTML] The cGAS–STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy
PK Oduro, X Zheng, J Wei, Y Yang, Y Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …
exert essential regulatory function in microbial-and onco-immunology through the induction …
STING inhibitors target the cyclic dinucleotide binding pocket
Z Hong, J Mei, C Li, G Bai, M Maimaiti… - Proceedings of the …, 2021 - National Acad Sciences
Cytosolic DNA activates cGAS (cytosolic DNA sensor cyclic AMP-GMP synthase)-STING
(stimulator of interferon genes) signaling, which triggers interferon and inflammatory …
(stimulator of interferon genes) signaling, which triggers interferon and inflammatory …