The Ramachandran plot is among the most central concepts in structural biology, seen in
publications and textbooks alike. However, with the increasing numbers of known protein …

A proper understanding of the detailed nature and mechanism of physicochemical
interactions depends heavily upon our ability to design and synthesize conformationally …

Many experimental and theoretical studies have suggested a significant role for nonnative
interactions in protein folding pathways, but the energetic contributions of these interactions …

Protein structures are classically described as composed of two regular states, the α-helices
and the β-strands and one non-regular and variable state, the coil. Nonetheless, this simple …

Four types of α, α-disubstituted amino acids {ie, α-aminoisobutyric acid (Aib), 1-
aminocyclopentanecarboxylic acid (Ac5c),(3S, 4S)-1-amino-(3, 4-dimethoxy) …

Solid-state NMR and molecular dynamics (MD) simulations are presented to help elucidate
the molecular secondary structure of poly (Gly-Gly-X), which is one of the most common …

The shortest helices (three-length 310 and four-length α), most abundant among helices of
different lengths, have been analyzed from a database of protein structures. A characteristic …

N‐terminal thiourea‐modified l‐Leu‐based peptide {(3, 5‐diCF3Ph) NHC (= S)‐(l‐Leu‐l‐
Leu‐Ac5c) 2‐OMe} with five‐membered ring α, α‐disubstituted α‐amino acids (Ac5c) …

Protein structures are highly dynamic macromolecules. This dynamics is often analysed
through experimental and/or computational methods only for an isolated or a limited number …

Chiral cyclic α, α‐disubstituted amino acids,(3S, 4S)‐and (3R, 4R)‐1‐amino‐3, 4‐(dialkoxy)
cyclopentanecarboxylic acids ((S, S)‐and (R, R)‐Ac5cdOR; R: methyl, methoxymethyl), were …