The restoration of myelin sheaths on demyelinated axons remains a major obstacle in the
treatment of multiple sclerosis (MS). Currently approved therapies work by modulating the …

Oligodendrocytes, the myelinating glial cells of the central nervous system (CNS), are due to
their high specialization and metabolic needs highly vulnerable to various insults. This led to …

Tumor necrosis factor-α (TNFα) and nitric oxide (NO), the product of inducible NO synthase
(iNOS), mediate inflammatory and immune responses in the CNS under a variety of …

Wrapping of the myelin sheath around axons by oligodendrocytes is critical for the rapid
conduction of electrical signals required for the normal functioning of the CNS. Myelination is …

Myelin is a biologically active membrane receiving and processing signals from axons.
Although much is known about its structure and molecular composition, the intracellular …

We have previously shown that myelin abnormalities characterize the normal aging process
of the brain and that an age-associated reduction in Klotho is conserved across species …

Interleukin-1 (IL-1) is a pleiotropic cytokine expressed during normal CNS development and
in inflammatory demyelinating diseases, but remarkably little is known about its effect on …

In this paper we address the linking of platelet-derived growth factor (PDGF) and basic
fibroblast growth factor (FGF-2) to intracellular signaling molecules in oligodendrocyte …

Oxidative stress is known to induce cell death in a wide variety of cell types, apparently by
modulating intracellular signaling pathways. In this study, we have examined the activation …

Multiple extracellular and intracellular signals regulate the functions of oligodendrocytes as
they progress through the complex process of developmental myelination and then maintain …