Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions

H Lu, Z Tian, Y Cui, Z Liu, X Ma - Comprehensive reviews in …, 2020 - Wiley Online Library
Chlorogenic acids (CGAs), a group of hydroxycinnamates, are generally abundant in
everyday foods and beverages, most prominently in certain coffee drinks. Among them, the …

Neuroprotective effects of coffee bioactive compounds: a review

K Socała, A Szopa, A Serefko, E Poleszak… - International journal of …, 2020 - mdpi.com
Coffee is one of the most widely consumed beverages worldwide. It is usually identified as a
stimulant because of a high content of caffeine. However, caffeine is not the only coffee …

The natural (poly) phenols as modulators of microglia polarization via TLR4/NF-κB pathway exert anti-inflammatory activity in ischemic stroke

R Li, Y Zhou, S Zhang, J Li, Y Zheng, X Fan - European journal of …, 2022 - Elsevier
Increasing evidences suggest that inflammation plays a key role in the pathogenesis of
stroke, a devastating disease second only to cardiac ischemia as a cause of death …

[HTML][HTML] Protective effects of chlorogenic acid on cerebral ischemia/reperfusion injury rats by regulating oxidative stress-related Nrf2 pathway

D Liu, H Wang, Y Zhang… - Drug design, development …, 2020 - pmc.ncbi.nlm.nih.gov
Results Step-down test and Y maze test showed that CGA dose-dependently mitigated CI/R-
induced brain damage and enhanced learning and spatial memory. Besides, CGA promoted …

Neuroprotective effect of artichoke-based nanoformulation in sporadic Alzheimer's disease mouse model: focus on antioxidant, anti-inflammatory, and amyloidogenic …

HAS El-Nashar, H Abbas, M Zewail, MH Noureldin… - Pharmaceuticals, 2022 - mdpi.com
The vast socio-economic impact of Alzheimer's disease (AD) has prompted the search for
new neuroprotective agents with good tolerability and safety profile. With its outstanding role …

Effects of chlorogenic acid on growth, metabolism, antioxidation, immunity, and intestinal flora of crucian carp (Carassius auratus)

X Jin, M Su, Y Liang, Y Li - Frontiers in Microbiology, 2023 - frontiersin.org
In recent years, with the harm caused by the abuse of antibiotics and the increasing demand
for green and healthy food, people gradually began to look for antibiotic alternatives for …

Exploring the multifaceted potential of chlorogenic acid: Journey from nutraceutical to nanomedicine

SK Singh, K Thakur, V Sharma, M Saini… - South African Journal of …, 2023 - Elsevier
Chlorogenic acid (CGA) is a naturally occurring polyphenolic acid from the family of
hydroxycinnamic acid, often found in green coffee extract and tea. CGA is chemically called …

Experimental pretreatment with chlorogenic acid prevents transient ischemia-induced cognitive decline and neuronal damage in the hippocampus through anti …

TK Lee, IJ Kang, B Kim, HJ Sim, DW Kim, JH Ahn… - Molecules, 2020 - mdpi.com
Chlorogenic acid (CGA), an ester of caffeic acid and quinic acid, is among the phenolic acid
compounds which can be naturally found in green coffee extract and tea. CGA has been …

Enhanced treatment of cerebral ischemia–Reperfusion injury by intelligent nanocarriers through the regulation of neurovascular units

H Lu, S Li, D Dai, Q Zhang, Z Min, C Yang, S Sun, L Ye… - Acta Biomaterialia, 2022 - Elsevier
Reperfusion injury is one of the major causes of disability and death caused by ischemic
stroke, and drug development focuses mainly on single neuron protection. However …

Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke

Y Wang, H Wu, Z Han, H Sheng, Y Wu, Y Wang, X Guo… - Phytomedicine, 2022 - Elsevier
Background As a leading cause of death and disability, alternative therapies for stroke are
still limited by its complicated pathophysiological manifestations. Guhong injection (GHI) …