Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Essential tremor (ET) is one of the most common movement disorders, with a reported> 60
million affected individuals worldwide. The definition and underlying pathophysiology of ET …

Recent advances in mitochondrial biology have revealed the high diversity and complexity
of proteolytic enzymes that regulate mitochondrial function. We have classified mitochondrial …

Essential tremor is one of the most common movement disorders. Despite its high
prevalence and heritability, the genetic aetiology of essential tremor remains elusive. Up to …

Mitochondrial impairment is a well-established pathological pathway implicated in
Parkinson's disease (PD). Defects of the complex I of the mitochondrial respiratory chain …

Genetic, environmental, and pharmacological interventions into the aging process can
confer resistance to multiple age‐related diseases in laboratory animals, including rhesus …

Aging and age-related neurodegeneration are both associated with the accumulation of
unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis …

In 1979, it was observed that parkinsonism could be induced by a toxin inhibiting
mitochondrial respiratory complex I. This initiated the long‐standing hypothesis that …

As neurons are highly energy-demanding cell, increasing evidence suggests that
mitochondria play a large role in several age-related neurodegenerative diseases. Synaptic …

Essential tremor (ET) and Parkinson's disease (PD) are the two most common tremor
disorders encountered in a movement disorders clinic. Although distinct clinical-pathological …