The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Mitochondrial ATP synthases form dimers, which assemble into long ribbons at the rims of
the inner membrane cristae. We reconstituted detergent-purified mitochondrial ATP …

Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

We used electron cryotomography of mitochondrial membranes from wild-type and mutant
Saccharomyces cerevisiae to investigate the structure and organization of ATP synthase …

Oxidative phosphorylation (OXPHOS) is the main source of energy in eukaryotic cells. This
process is performed by means of electron flow between four enzymes, of which three are …

We used electron cryotomography to study the molecular arrangement of large respiratory
chain complexes in mitochondria from bovine heart, potato, and three types of fungi. Long …

To broadly explore mitochondrial structure and function as well as the communication of
mitochondria with other cellular pathways, we constructed a quantitative, high-density …

Mitochondria are complex organelles with two membranes. Their architecture is determined
by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and …

Mitochondria are central to cell function. The placenta forms the interface between maternal
and fetal systems, and placental mitochondria have critical roles in maintaining pregnancy …