Cells have a remarkable ability to synthesize large amounts of protein in a very short period
of time. Under these conditions, many hydrophobic surfaces on proteins may be transiently …

Purpose Epigenetic processes are implicated in cancer causation and progression. The
acetylation status of histones regulates access of transcription factors to DNA and influences …

Cancer chemotherapy is frequently hampered by drug resistance. Concepts to combine
anticancer drugs with different modes of action to avoid the development of resistance did …

Stress or heat shock proteins (HSPs) 70 and 90 are powerful chaperones whose expression
is induced in response to a wide variety of physiological and environmental insults. These …

Histone deacetylases (HDACs) can regulate expression of tumor suppressor genes and
activities of transcriptional factors involved in both cancer initiation and progression through …

The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and
EED, in which the SET (suppressor of variegation–enhancer of zeste-trithorax) domain of …

When cancer cells develop resistance to chemotherapeutics, it is frequently conferred by the
ATP-dependent efflux pump P-glycoprotein (MDR1, P-gp, ABCB1). P-gp can efflux a wide …

Multidrug resistance (MDR), which is related to cancer chemotherapy, tumor stem cells, and
tumor metastasis, is a huge obstacle for the effective cancer therapy. One of the underlying …

Histone deacetylases (HDACs) have emerged as attractive drug targets, particularly for
neoplastic indications. This large family is divided into four classes, of which three consist of …

Autophagy is an evolutionarily conserved cell survival pathway that enables cells to recoup
ATP and other critical biosynthetic molecules during nutrient deprivation or exposure to …