Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues

DB Hier, T Obafemi-Ajayi, MS Thimgan, GR Olbricht… - Biomarker …, 2021 - Springer
Background The use of blood biomarkers after mild traumatic brain injury (mTBI) has been
widely studied. We have identified eight unresolved issues related to the use of five …

Role of biomarkers and emerging technologies in defining and assessing neurobiological recovery after sport-related concussion: a systematic review

JB Tabor, BL Brett, L Nelson, T Meier… - British journal of sports …, 2023 - bjsm.bmj.com
Objective Determine the role of fluid-based biomarkers, advanced neuroimaging, genetic
testing and emerging technologies in defining and assessing neurobiological recovery after …

Unique diagnostic signatures of concussion in the saliva of male athletes: the Study of Concussion in Rugby Union through MicroRNAs (SCRUM)

V Di Pietro, P O'Halloran, CN Watson… - British journal of sports …, 2021 - bjsm.bmj.com
Objective To investigate the role of salivary small non-coding RNAs (sncRNAs) in the
diagnosis of sport-related concussion. Methods Saliva was obtained from male professional …

A framework to advance biomarker development in the diagnosis, outcome prediction, and treatment of traumatic brain injury

EA Wilde, IB Wanner, K Kenney, J Gill… - Journal of …, 2022 - liebertpub.com
Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …

The 2022 lady estelle wolfson lectureship on neurofilaments

A Petzold - Journal of neurochemistry, 2022 - Wiley Online Library
Neurofilament proteins (Nf) have been validated and established as a reliable body fluid
biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light …

Serum tau, neurofilament light chain, glial fibrillary acidic protein, and ubiquitin carboxyl-terminal hydrolase L1 are associated with the chronic deterioration of …

RT Lange, S Lippa, TA Brickell, J Gill… - Journal of …, 2023 - liebertpub.com
The purpose of this study was to examine the association of serum tau, neurofilament light
chain (NFL), glial fibrillary acidic protein (GFAP), and ubiquitin carboxy-terminal hydrolase …

[HTML][HTML] Neurochemical markers of traumatic brain injury: relevance to acute diagnostics, disease monitoring, and neuropsychiatric outcome prediction

P Shahim, H Zetterberg - Biological psychiatry, 2022 - Elsevier
Considerable advancements have been made in the quantification of biofluid-based
biomarkers for traumatic brain injury (TBI), which provide a clinically accessible window to …

Neurofilament light chain in patients with a concussion or head impacts: a systematic review and meta-analysis

E Karantali, D Kazis, J McKenna… - European journal of …, 2022 - Springer
Purpose Traumatic brain injury is one of the leading causes of disability worldwide. Mild
traumatic brain injury (TBI) is the most common and benign form of TBI, usually referred to by …

A kinetic model for blood biomarker levels after mild traumatic brain injury

S Azizi, DB Hier, B Allen, T Obafemi-Ajayi… - Frontiers in …, 2021 - frontiersin.org
Traumatic brain injury (TBI) imposes a significant economic and social burden. The
diagnosis and prognosis of mild TBI, also called concussion, is challenging. Concussions …

Association of plasma biomarker levels with their CSF concentration and the number and severity of concussions in professional athletes

P Shahim, H Zetterberg, J Simrén, NJ Ashton… - Neurology, 2022 - AAN Enterprises
Background and Objectives To examine whether the brain biomarkers total-tau (T-tau), glial
fibrillary acidic protein (GFAP), and β-amyloid (Aβ) isomers 40 and 42 in plasma relate to the …