Pharmacokinetics and pharmacodynamics of approved and investigational P2Y12 receptor antagonists

U Schilling, J Dingemanse, M Ufer - Clinical Pharmacokinetics, 2020 - Springer
Coronary artery disease remains the major cause of mortality worldwide. Antiplatelet drugs
such as acetylsalicylic acid and P2Y12 receptor antagonists are cornerstone treatments for …

Association of ticagrelor vs clopidogrel with net adverse clinical events in patients with acute coronary syndrome undergoing percutaneous coronary intervention

SC You, Y Rho, B Bikdeli, J Kim, A Siapos, J Weaver… - Jama, 2020 - jamanetwork.com
Importance Current guidelines recommend ticagrelor as the preferred P2Y12 platelet
inhibitor for patients with acute coronary syndrome (ACS), primarily based on a single large …

Comparison of clinical outcomes between ticagrelor and clopidogrel in acute coronary syndrome: a comprehensive meta-analysis

M Sun, W Cui, L Li - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
Background Ticagrelor is currently recommended for patients with the acute coronary
syndrome (ACS). However, recent studies have yielded controversial results. Objective To …

Ticagrelor use in acute myocardial infarction: insights from the National Cardiovascular Data Registry

SS Basra, TY Wang, DJN Simon… - Journal of the …, 2018 - Am Heart Assoc
Background Ticagrelor is a P2Y12 receptor inhibitor with superior clinical efficacy compared
with clopidogrel. However, it is associated with reduced efficacy when combined with a high …

Real-world data of prasugrel vs. ticagrelor in acute myocardial infarction: results from the RENAMI registry

O De Filippo, M Cortese, FD´ Ascenzo… - American Journal of …, 2019 - Springer
Background Limited data are available concerning differences in clinical outcomes for real-
life patients treated with ticagrelor versus prasugrel after percutaneous coronary intervention …

Prasugrel vs. ticagrelor for acute coronary syndrome patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

MS Khan, MM Memon, MS Usman, S Alnaimat… - American Journal of …, 2019 - Springer
Abstract Background The newer P2Y 12 inhibitors have better efficacy than clopidogrel.
However, whether ticagrelor or prasugrel have a better comparative safety and efficacy …

Comparison of prasugrel and ticagrelor in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a meta-analysis of randomized and …

H Watti, K Dahal, HG Zabher, P Katikaneni… - International journal of …, 2017 - Elsevier
Background The newer oral P2Y12 receptor antagonists (ie prasugrel and ticagrelor) are
recommended over clopidogrel for patients with acute coronary syndrome (ACS) going for …

Clopidogrel, prasugrel, or ticagrelor use and clinical outcome in patients with acute coronary syndrome: a nationwide long-term registry analysis from 2009 to 2014

SS Rezaei, A Geroldinger, G Heinze… - International Journal of …, 2017 - Elsevier
Background The beneficial use of dual antiplatelet therapy (DAPT) with acetylsalicylic acid
(ASA) and P2Y12 õinhibitors has been established for patients after acute coronary …

Safety and efficacy of prasugrel and ticagrelor in acute coronary syndrome. Results of a “real world” multicenter registry

M Almendro-Delia, Á García-Alcántara… - Revista Española de …, 2017 - Elsevier
Introduction and objectives The incorporation of the new antiplatelet agents (NAA) prasugrel
and ticagrelor into routine clinical practice is irregular and data from the “real world” remain …

Bleeding severity in percutaneous coronary intervention (PCI) and its impact on short-term clinical outcomes

S Murali, S Vogrin, S Noaman, DT Dinh… - Journal of clinical …, 2020 - mdpi.com
Bleeding severity in patients undergoing percutaneous coronary intervention (PCI), defined
by the Bleeding Academic Research Consortium (BARC), portends adverse prognosis. We …