The degeneration of nigral dopaminergic neurons is considered the hallmark of Parkinson's
disease (PD), and it is triggered by different factors, including mitochondrial dysfunction …

Variants in the GBA1 and LRRK2 genes are the most common genetic risk factors
associated with Parkinson disease (PD). Both genes are associated with lysosomal and …

Leucine-rich repeat kinase 2 (LRRK2) is a multidomain scaffolding protein with dual
guanosine triphosphatase (GTPase) and kinase enzymatic activities, providing this protein …

Neural activity is finely tuned to produce normal behaviors, and disruptions in activity likely
occur early in the course of many neurodegenerative diseases. However, how neural activity …

The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with
late-onset Parkinson's disease (PD). Although PD affects men and women differently …

Alcohol consumption is associated with alterations in memory and learning processes in
humans and animals. In this context, research models such as the zebrafish (Danio rerio) …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the
degeneration of dopamine neurons in the substantia nigra pars compacta, leading to motor …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic forms of Parkinson's disease (PD). Sporadic PD and LRRK2 PD share main clinical …

Neurotransmitter transporters (NTTs) control synaptic responses by modulating the
concentration of neurotransmitters at the synaptic cleft. Glutamate is the most abundant …

In Parkinson's disease (PD), axons of dopaminergic (DA) neurons in the substantia nigra
pars compacta (SNc) degenerate before their cell bodies. Calcium influx during pacemaker …