The past two decades have witnessed a wide range of studies investigating genetic variants
of voltage‐gated sodium (NaV) channels, which are involved in a broad spectrum of …

Background Lyme neuroborreliosis, caused by the bacterium Borrelia burgdorferi affects
both the central and peripheral nervous systems (CNS, PNS). The CNS manifestations …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among
patients with epilepsy, causing a global public health burden. The underlying mechanisms …

Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth
factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in …

Summary Objective Fibroblast Growth Factor 12 (FGF12) may represent an important
modulator of neuronal network activity and has been associated with developmental and …

Developmental and epileptic encephalopathies (DEEs), a class of devastating neurological
disorders characterized by recurrent seizures and exacerbated by disruptions to …

Abstract Fibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor
homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The …

The prevalence of seizures in individuals with fragile X syndrome (FXS) is~ 25%; however,
there are no reports of spontaneous seizures in the Fmr1 knockout mouse model of FXS …

Galectins constitute a class of lectins that specifically interact with β-galactoside sugars in
glycoconjugates and are implicated in diverse cellular processes, including transport …

Background Sudden unexplained death (SUD) is a devastating event in the young. Despite
efforts to identify causal genetic variants, many cases remain unexplained after genetic …