Detection and discrimination of neutron capture events for NCEPT dose quantification

A Chacon, M Kielly, H Rutherford, DR Franklin… - Scientific reports, 2022 - nature.com
Abstract Neutron Capture Enhanced Particle Therapy (NCEPT) boosts the effectiveness of
particle therapy by capturing thermal neutrons produced by beam-target nuclear interactions …

Monte Carlo-calculated beam quality and perturbation correction factors validated against experiments for Farmer and Markus type ionization chambers in therapeutic …

Y Urago, M Sakama, D Sakata, S Fukuda… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. In current dosimetry protocols, the estimated uncertainty of the measured
absorbed dose to water D w in carbon-ion beams is approximately 3%. This large …

A validated Geant4 model of a whole-body PET scanner with four-layer DOI detectors

AM Ahmed, A Chacon, H Rutherford… - Physics in Medicine …, 2020 - iopscience.iop.org
The purpose of this work is to develop a validated Geant4 simulation model of a whole-body
prototype PET scanner constructed from the four-layer depth-of-interaction detectors …

First experimental demonstration of real-time neutron capture discrimination in helium and carbon ion therapy

M Kielly, A Caracciolo, A Chacon, J Vohradsky… - Scientific Reports, 2024 - nature.com
This work provides the first experimental proof of an increased neutron capture photon
signal following the introduction of boron to a PMMA phantom during helium and carbon ion …

Influence of momentum acceptance on range monitoring of 11C and 15O ion beams using in-beam PET

A Mohammadi, H Tashima, Y Iwao… - Physics in Medicine …, 2020 - iopscience.iop.org
In heavy-ion therapy, the stopping position of primary ions in tumours needs to be monitored
for effective treatment and to prevent overdose exposure to normal tissues. Positron-emitting …

An inception network for positron emission tomography based dose estimation in carbon ion therapy

H Rutherford, RS Turai, A Chacon… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective. We aim to evaluate a method for estimating 1D physical dose deposition profiles
in carbon ion therapy via analysis of dynamic PET images using a deep residual learning …

Experimental investigation of the characteristics of radioactive beams for heavy ion therapy

A Chacon, B James, L Tran, S Guatelli… - Medical …, 2020 - Wiley Online Library
Purpose This work has two related objectives. The first is to estimate the relative biological
effectiveness of two radioactive heavy ion beams based on experimental measurements …

Development of a more accurate Geant4 quantum molecular dynamics model for hadron therapy

Y Sato, D Sakata, D Bolst, EC Simpson… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective. Although in heavy-ion therapy, the quantum molecular dynamics (QMD) model is
one of the most fundamental physics models providing an accurate daughter-ion production …

Impacts of Geant4 hadronic physics models on secondary particle productions in proton therapy simulations

PTC Lai, VH Hai, NTT Phuc - Radiation Physics and Chemistry, 2025 - Elsevier
Monte Carlo simulations using the Geant4 toolkit are widely used in proton therapy to predict
the dose distribution and secondary particle production. The choice of physics models used …

Dose quantification in carbon ion therapy using in-beam positron emission tomography

H Rutherford, A Chacon, A Mohammadi… - Physics in Medicine …, 2020 - iopscience.iop.org
This work presents an iterative method for the estimation of the absolute dose distribution in
patients undergoing carbon ion therapy, via analysis of the distribution of positron …