Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

Organism viability relies on the stable maintenance of specific chromatin landscapes,
established during development, that shape cell functions and identities by driving distinct …

RNA-DNA hybrids are a major internal cause of DNA damage within cells, and their
degradation by RNase H enzymes is important for maintaining genomic stability. Here, we …

Histone modifications establish the chromatin states that coordinate the DNA damage
response. In this study, we show that SETD2, the enzyme that trimethylates histone H3 …

Abstract FAcilitates Chromatin Transcription (FACT) has been considered essential for
transcription through chromatin mostly based on cell-free experiments. However, FACT …

Abstract STING (Stimulator of Interferon Genes) is an endoplasmic reticulum-anchored
adaptor of the innate immunity best known to trigger pro-inflammatory cytokine expression in …

Quinacrine, also known as mepacrine, has originally been used as an antimalarial drug for
close to a century, but was recently rediscovered as an anticancer agent. The mechanisms …

Much of the HSV-1 life cycle is carried out in the cell nucleus, including the expression,
replication, repair, and packaging of viral genomes. Viral proteins, as well as cellular factors …

DNA damage challenges both genome integrity and its organization with histone proteins
into chromatin, with prominent alterations in histone variant dynamics and histone …

The MYC oncoprotein globally affects the function of RNA polymerase II (RNAPII). The ability
of MYC to promote transcription elongation depends on its ubiquitylation. Here, we show …