Abstract'Cellular senescence', a term originally defining the characteristics of cultured cells
that exceed their replicative limit, has been broadened to describe durable states of …

The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …

Abstract The European Commission asked EFSA to update their 2006 opinion on ochratoxin
A (OTA) in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and …

Ascorbate (vitamin C) was an early, unorthodox therapy for cancer, with an outstanding
safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two …

We demonstrate that concurrent administration of poly (ADP-ribose) polymerase (PARP)
and WEE1 inhibitors is effective in inhibiting tumor growth but poorly tolerated. Concurrent …

Histone H3. 3 is a highly conserved histone H3 replacement variant in metazoans and has
been implicated in many important biological processes, including cell differentiation and …

When a human cell detects damaged DNA, it initiates the DNA damage response (DDR) that
permits it to repair the damage and avoid transmitting it to daughter cells. Despite this …

The decline of tissue regenerative potential with age correlates with impaired stem cell
function. However, limited strategies are available for therapeutic modulation of stem cell …

Polyploidy (alias whole genome amplification) refers to organisms containing more than two
basic sets of chromosomes. Polyploidy was first observed in plants more than a century ago …

Age-related accumulation of ploidy changes is associated with decreased expression of
genes controlling chromosome segregation and cohesin functions. To determine the …