Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous
disease. Transcriptomic and genetic characterization of DLBCL has increased the …

Hypoxia is a condition commonly observed in the core of solid tumors. The hypoxia-
inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response …

Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of hematological
malignancies. Compared to our knowledge of B-cell tumors, our understanding of T-cell …

Tumors remodel their metabolism to support anabolic processes needed for replication, as
well as to survive nutrient scarcity and oxidative stress imposed by their changing …

Overexpression of fatty acid synthase (FASN), a key regulator of the de novo synthesis of
fatty acids, has been demonstrated in a variety of cancers and is associated with poor …

Cancer-specific perturbations of signaling, metabolism, and epigenetics can be a cause
and/or consequence of malignant transformation. Evidence indicates that these regulatory …

Abstract Fatty acid synthase (EC 2.3. 1.85; FASN) is a multifunctional enzyme system that
catalyzes the formation of fatty acids from acetyl-CoA, malonyl-CoA, and NADPH and plays …

Along with direct anticancer activity, curcumin hinders the onset of chemoresistance. Among
many, high glucose condition is a key driving factor for chemoresistance. However, the …