Histidine, a versatile proteinogenic amino acid, plays a broad range of roles in all living
organisms and behaves as a key mediator of the interactions of biomolecules with inorganic …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …

The mechanism (or mechanisms) of enthalpy–entropy (H/S) compensation in protein–ligand
binding remains controversial, and there are still no predictive models (theoretical or …

Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …

Abstract MetalPDB (http://metalweb. cerm. unifi. it/) is a database providing information on
metal-binding sites detected in the three-dimensional (3D) structures of biological …

Protein‐metal interactions—traditionally regarded for roles in metabolic processes—are now
known to enhance the performance of certain biogenic materials, influencing properties …

Carbonic anhydrases (CAs I-VII) are products of a gene family that encodes seven isozymes
and several homologous, CA-related proteins. All seven isozymes have been cloned …

The two-volume Encyclopedia of Supramolecular Chemistry offers authoritative, centralized
information on a rapidly expanding interdisciplinary field. User-friendly and high-quality …

Ever since its discovery at the University of Pennsylvania1 and the University of Cambridge2
more than 60 years ago, the zinc enzyme carbonic anhydrase has occupied a prominent …

While the chemist of today faces many exciting and stimulating challenges, perhaps the
most demanding, promising, and rewarding one is the rational design of novel therapeutic …